UCL Institute of Child Health London UK
Contact information:
Institute & address
UCL Institute of Child Health,
30 Guilford Street
London WC1N 1EH
Tel : 44 (0) 207 905 2391
Fax : 44 (0) 207 905 2882
Email: l.wedderburn@ucl.ac.uk
Who is who?
PI’s and Key staff members and expertise:
PI Lucy Wedderburn, Professor of Paediatric Rheumatology
Director, Arthritis Research UK Centre for Adolescent Rheumatology at UCL , UCLH and GOSH
Deputy Head, Infection, Immunity and Inflammation Programme, UCL Institute of Child Health – Unit website
Section teams Clinical and Lab:
Prof Paul Brogan, Professor of Vasculitis, Head of Infection, Inflammation and Rheumatology Section and Consultant Paediatric Rheumatology
Dr Despina Eleftheriou Clinical Fellow and Consultant Paediatric Rheumatology
Clinical:
Dr Clarissa Pilkington, Consultant Paediatric Rheumatology
Dr Sandrine Lacassagne Consultant Paediatric Rheumatology
Dr Muthana Al Obadi Consultant Paediatric Rheumatology
Dr Debajit Sen, Adolescent Rheumatology Consultant
Ms Sue Maillard Clinical Specialist Physiotherapist in Paediatric Rheumatology
Lab:
Wedderburn group:
Dr Clare Deakin, Research Associate
Ms Chantal Duurland, EUTRAIN PhD Fellow/Research Assistant
Ms Lucy Marshall, Research Assistant
Ms Hannah Lom, PhD Student, Arthritis Research UK Centre for Adolescent Rheumatology
Dr Jason Palman, Clinical Research Associate
Dr Lizzy Rosser, Arthritis Research UK post doctoral Foundation Fellow
Dr Sherry Yasin, Research Associate
Support Staff
Ms Brenda Bell, Administrator, Centre for Adolescent Rheumatology
Ms Hema Chaplin, Research Facilitator
Ms Yvonne Glackin, POPS/SLE Study Coordinator
Ms Clare Heard, CHART Study Coordinator
Ms Natasha Makengo, CAPS Data Manager
Ms Emily Robinson, JIA Study Coordinator
Ms Stephanie Simou, JDRG Study Coordinator
Short summary research:
The key focus of the Wedderburn laboratory is the immunopathogenesis of childhood arthritis and myositis, with emphasis on immune regulation, in particular T cell responses and regulatory T cells and the dynamic immunomodulation driven by inflammation. My group has a major programme of work focusing on the mechanisms of severity of disease and predictors of response to medication. We lead a large study of response to drug treatment in JIA known as Childhood Arthritis Response to Medication Study or CHARMS with National and International partners and a UK wide Consortium CHART that is bringing together 4 key large cohort studies in JIA from across the UK
L Wedderburn leads the UK wide cohort study in juvenile dermatomyositis (JDM), a resource which acts as a platform for basic translational and clinical research into JDM see http://www.juveniledermatomyositis.org.uk and is the Director of the Arthritis Research UK Centre for Adolescent Rheumatology at UCL, UCLH and GOSH , http://www.centre-for-adolescent-rheumatology.org
Our translational research programme is aimed at the design of biomarkers and predictors of outcome and response to treatment with the ultimate goal of designing diagnostic and therapeutic predictive tools to facilitate personalized medicine and ultimately improve the lives of children with autoimmune rheumatic diseases.
Our group is fully integrated into the National effort of research in Paediatric Rheumatology through contributions to the Clinical Studies group in Paediatric Rheumatology http://www.arthritisresearchuk.org/arthritis_research/clinical_study_groups/csg_-_mcrn_paediatric_rheumato.aspx
the British Society for Paediatric and Adolescent Rheumatology
Funding sources:
Medical Research Council
National Institute for Health Research
Relevant links:
Standardised operating procedure (SOP) for collection and processing of bio-‐ specimens in studies of juvenile idiopathic arthritis (JIA) in association with the Childhood Arthritis response to Treatment Consortium, CHART:
CHART_SOP_PACKAGE final 020316